Structure elucidation of dimeric transmembrane domains of bitopic proteins
نویسندگان
چکیده
منابع مشابه
TMDIM: an improved algorithm for the structure prediction of transmembrane domains of bitopic dimers
[Formula: see text]-Helical transmembrane proteins are the most important drug targets in rational drug development. However, solving the experimental structures of these proteins remains difficult, therefore computational methods to accurately and efficiently predict the structures are in great demand. We present an improved structure prediction method TMDIM based on Park et al. (Proteins 57:5...
متن کاملStructural aspects of oligomerization taking place between the transmembrane alpha-helices of bitopic membrane proteins.
Recent advances in biophysical methods have been able to shed more light on the structures of helical bundles formed by the transmembrane segments of bitopic membrane proteins. In this manuscript, I attempt to review the biological importance and diversity of these interactions, the energetics of bundle formation, motifs capable of inducing oligomerization and methods capable of detecting, solv...
متن کاملStructure Elucidation of Transmembrane Proteins using Public-Available Databases and Experimental Data on Competitive Inhibition.
We present an approach towards structure elucidation of bilitranslocase, the membrane protein which transports bilirubin from blood to liver cells. The sequence and secondary structure information of transmembrane segments of proteins with known 3D structure is exploited to predict the transmembrane domains of structurally unresolved target protein. With the help of known structures the transme...
متن کاملStructure Prediction of Proteins with Transmembrane Helices
Many sophisticated methods have been applied to the prediction of structure and function of protein sequences which are derived from the genome projects. However, difficulties of prediction for some protein types, e.g., membrane proteins, are not still resolved due to the lack of their 3D structure information. Although membrane proteins are minor fraction of the genome, the biological function...
متن کاملthe structure of lie derivations on c*-algebras
نشان می دهیم که هر اشتقاق لی روی یک c^*-جبر به شکل استاندارد است، یعنی می تواند به طور یکتا به مجموع یک اشتقاق لی و یک اثر مرکز مقدار تجزیه شود. کلمات کلیدی: اشتقاق، اشتقاق لی، c^*-جبر.
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2010
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.4.2.11930